Role of the Metabolic Minor Components in the Regulation of Intermolecular Interaction

This work presents a study of intermolecular interactions using the model of the antigen antibody interactions of the ABO system. Absence of knowledge in the field of the ABO antigen’s behavior as a biomolecule and the integration of these structures into cascade of metabolic and physiological processes create the conditions, which promote a successful using this new model in the future. Molecular recognition and designing are included into the main catalog of computer methods of research, which is called “in silico”. Using PASS system, we describe the possible biological effects of pyruvate, lactate, antigen determinants A and B. Pharmacological effects and molecular mechanisms of influence on activity of the factors regulating inside and intercellular interactions are predicted for such minor components as pyruvate and lactate. Due to variety of the biological effects, glycoproteins A and B are very perspective to study as biological active connections. The obtained knowledge proves that AB0 antigens, as well as other glycoprotein conjugates are important mediators of intercellular adhesion and participants of signal transmission. Using ABO blood group system as a model helped to describe individual differences of parameters—degree and time of the agglutination beginning of antigen/antibody blood types of the AB0—are revealed.